Protocols thatmove the needle.
Every protocol is graded by evidence level, linked to your biomarker results, and updated as new research emerges. No wellness fluff — only clinically-referenced interventions.
NAD+ / NMN Protocol
Restore the fuel your mitochondria need to function optimally.
NMN is a direct precursor to NAD+, which declines ~50% by age 50. A 2023 RCT (n=80) showed 300–900mg NMN daily increased blood NAD+ significantly with no safety issues in 60 days. A 2024 study found 250mg/day improved walking speed and sleep quality in older adults after 12 weeks.
Senolytic Protocol
Clear the cellular debris that accelerates every hallmark of aging.
Senolytics target and eliminate senescent 'zombie' cells that accumulate with age and drive systemic inflammation. 2024 Mayo Clinic study showed Quercetin + Dasatinib eliminated aging cells and extended lifespan in animal models by over 30%. Fisetin showed similar effects in human pilot trials.
Hormone Optimization
Recalibrate your endocrine system for peak performance and longevity.
Hormone optimization using peptide therapy and bioidentical hormones to maintain youthful hormonal balance. A 2024 Journal of Endocrinology study found GHRPs like CJC-1295 increased IGF-1 by 28% and improved body composition over 12 weeks. Requires physician oversight and baseline hormone panel.
Autophagy Fasting
Activate your body's cellular recycling system to clear damaged proteins.
Prolonged fasting triggers autophagy — the cellular self-cleaning process where damaged organelles and misfolded proteins are degraded and recycled. Nobel Prize-winning research (Yoshinori Ohsumi, 2016) established autophagy's role in aging, neurodegeneration, and cancer prevention.
Methylation Optimization
Fix the epigenetic switches that control your gene expression.
MTHFR variants affect up to 40% of the population and impair methylation — a critical process for DNA repair, neurotransmitter synthesis, and detoxification. Optimizing methylation can reverse epigenetic aging markers within 8 weeks.
Mitochondrial Biogenesis
Build more mitochondria — the powerhouses that determine your energy ceiling.
Mitochondrial density declines 10% per decade after age 30. This protocol combines Zone 2 cardio, cold exposure, and targeted supplementation to stimulate PGC-1α — the master regulator of mitochondrial biogenesis.
Medical Disclaimer
These protocols are for educational purposes and represent synthesized research summaries. They are not medical advice and should not replace consultation with a qualified physician. Always consult a licensed healthcare provider before beginning any supplement, peptide, or fasting protocol — especially if you have pre-existing conditions or take prescription medications. VitalityBio connects you with licensed clinicians for personalized guidance.